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NMR Validation

NMR spectroscopy provides a means to evaluate material with high compound and high material specificity.  Information as to the chemical structure, stereochemistry, quantity, material composition, and material identity is encoded in the NMR spectrum. The high reproducibility of NMR spectroscopy from instrument to instrument and lab to lab makes NMR an excellent tool for material validation. Approaches to utilizing NMR as a material validation tool include using

(1) targeted approaches, the identification and quantification of specific components, and
(2) non-targeted approaches, the use of chemometric methods to evaluate the spectrum as a whole. 

Efforts to increase the number and the speed of validated NMR methods are underway. This promises to move NMR technology from R&D to a mainstream analytical tool for production leading to high quality product assessment.

Quantitative NMR spectroscopy (qNMR) provides the most universally applicable form of direct purity determination without the need for reference materials of analytes or the calculation of relative response factors, with the only requirement being the exhibition of suitable NMR spectral properties. Due to recent advances in the technical development of NMR instruments, such as acquisition electronics and probe design, detection limits of components in liquid mixtures have been improved into the lower ppm range (approx. 5–10 ppm amount of substance).

The development of validated procedures and qualified standards will give users the tools to routinely exploit qNMR and enable them to, in some cases, speed up analytical method development, with the added advantage of reducing the time and financial burden of multiple analytical testing.

NMR has been developed to a point where it is now available for routine testing and analysis. The PANIC validation group proposes to become a driving force in getting NMR methods with qualified standards validated, publicized, and supported by documentation. The organization will also provide a mechanism for repeatability/reproducibility assessment of NMR methods and promote round-robin studies through the development of a network of NMR spectroscopy users that are involved in NMR validation. A desired outcome is to position this NMR validation group to establish best practices for validating NMR methods. We aim to make NMR method validations more streamlined, so that those methods will be easier to implement and more commonly used in industry. This will result in increased application of NMR and improve its acceptance by the analytical community across all industry sectors.

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